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Antimicrobial Agents and Chemotherapy, August 2003, p. 2663-2665, Vol. 47, No. 8
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.8.2663-2665.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Efficacy of Single-Dose Azithromycin in Treatment of Acute Otitis Media in Children after a Baseline Tympanocentesis

Michael W. Dunne,1* Chandra Khurana,2 Adriano Arguedas Mohs,3 Adib Rodriguez,4 Antonio Arrieta,5 Samuel McLinn,6 Judy A. Krogstad,7 Mark Blatter,8 Richard Schwartz,9 Sergio L. Vargas,10 Paz Emparanza,11 Pilar Fernandez,12 Willis M. Gooch III,13 Mary Aspin,14 John Podgore,15 Irmeli Roine,16 Jeffrey L. Blumer,17 Garth D. Ehrlich,18 and Jean Chow19

Pfizer Global Research & Development, New London, Connecticut,1 Maya Family Medical Center, Chicago, Illinois,2 Hospital Nacional de Niños and Neeman-ICIC, San Jose, Costa Rica,3 Hospital Infantil Juan Pablo II, Guatemala City, Guatemala,4 Children's Hospital of Orange County, Orange,5 Pediatrics Plus, Clovis,7 Children's Hospital and Health Center, San Diego, California,14 Scottsdale Pediatric Center, Scottsdale, Arizona,6 Primary Physicians Research,8 Center for Genomic Sciences, Allegheny Singer Research Institute and Department of Microbiology and Immunology, MCP Hahnemann School of Medicine, Pittsburgh, Pennsylvania,18 Vienna Pediatric Associates, Vienna, Virginia,9 Clinical Research Group, University of Chile School of Medicine,10 Centro Médico OTOMED,11 Hospital Clinico Universidad de Chile,12 Hospital Luis Calvo Mackenna, Santiago, Chile,16 Hill Top Research, Inc., Salt Lake City, Utah,13 University of North Texas Health Science Center at Ft. Worth, Department of Pediatrics, Ft. Worth, Texas,15 Rainbow Babies and Children's Hospital, Cleveland, Ohio,17 Pfizer, Inc., New York, New York,19

Received 25 November 2002/ Returned for modification 17 February 2003/ Accepted 7 May 2003

Children with acute otitis media underwent tympanocentesis and were given a single dose of 30 mg of azithromycin/kg of body weight. At day 28, the overall clinical cure rate was 206 of 242 (85%). Clinical cure rates for patients infected with Streptococcus pneumoniae (67 of 76; 88%) and Haemophilus influenzae (28 of 44; 64%) were consistent with historical rates for the 5-day dosing regimen.

* Corresponding author. Mailing address: Pfizer Global Research and Development, 50 Pequot Ave., MS6025-C2173, New London, CT 06320. Phone: (860) 732-3739. Fax: (860) 732-5702. E-mail: michael_w_dunne{at}groton.pfizer.com.

Antimicrobial Agents and Chemotherapy, August 2003, p. 2663-2665, Vol. 47, No. 8
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.8.2663-2665.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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