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Antimicrobial Agents and Chemotherapy, August 2003, p. 2666-2668, Vol. 47, No. 8
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.8.2666-2668.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

{alpha}-Defensin 1 (Human Neutrophil Protein 1) as an Antichemotactic Agent for Human Polymorphonuclear Leukocytes

P. S. Grutkoski,1 C. T. Graeber,1 Y. P. Lim,2 A. Ayala,1 and H. H. Simms3*

Departments of Surgery,1 Medical Oncology, Rhode Island Hospital, Providence, Rhode Island 02903,2 Department of Surgery, North Shore-Long Island Jewish Hospitals, New York University School of Medicine, Manhasset, New York 110303

Received 18 December 2002/ Returned for modification 3 March 2003/ Accepted 10 May 2003

Medium conditioned by tumor necrosis factor alpha (TNF-{alpha})-stimulated polymorphonuclear leukocytes (PMN) (CM-TNF) suppresses PMN migration. Therefore, we wished to identify the agent(s) in CM-TNF that mediated antichemotactic activity. CM-TNF was fractionated by high-performance liquid chromatography, and one fraction with antichemotactic activity contained the bactericidal protein human neutrophil protein 1 (HNP-1). We showed that HNP-1 suppresses PMN migration to formyl-methionyl-leucyl-phenylalanine but not to interleukin 8.

* Corresponding author. Mailing address: Department of Surgery, North Shore University Hospital, 300 Community Dr., 6 Monti, Manhasset, NY 11030. Phone: (516) 562-2870. Fax: (516) 562-4821. E-mail: hsimms{at}nshs.edu.

Antimicrobial Agents and Chemotherapy, August 2003, p. 2666-2668, Vol. 47, No. 8
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.8.2666-2668.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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