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Antimicrobial Agents and Chemotherapy, August 2003, p. 2688-2691, Vol. 47, No. 8
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.8.2688-2691.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Bovine Lactoferrin Inhibits Adenovirus Infection by Interacting with Viral Structural Polypeptides

Agostina Pietrantoni,1 Assunta Maria Di Biase,1 Antonella Tinari,1 Magda Marchetti,1 Piera Valenti,2 Lucilla Seganti,3 and Fabiana Superti1*

Department of Ultrastructure, Istituto Superiore di Sanità,1 Department of Public Health Sciences, University La Sapienza, Rome,3 Department of Experimental Medicine, II University of Naples, Naples, Italy2

Received 11 December 2002/ Returned for modification 17 March 2003/ Accepted 8 May 2003

We recently demonstrated that lactoferrin, an antimicrobial glycoprotein, can inhibit adenovirus infection by competing for common glycosaminoglycan receptors. This study further characterizes the antiadenovirus activity of the protein, thus demonstrating that lactoferrin neutralizes infection by binding to adenovirus particles and that its targets are viral III and IIIa structural polypeptides.

* Corresponding author. Mailing address: Department of Ultrastructure, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy. Phone: 39/0649902955. Fax: 39/0649387140. E-mail: superti{at}iss.it.

Antimicrobial Agents and Chemotherapy, August 2003, p. 2688-2691, Vol. 47, No. 8
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.8.2688-2691.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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