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Antimicrobial Agents and Chemotherapy, September 2003, p. 2971-2973, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.2971-2973.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Discordant Resistance to Kanamycin and Amikacin in Drug-Resistant Mycobacterium tuberculosis

Annika Krüüner,1,2,3* Pontus Jureen,1 Klavdia Levina,4 Solomon Ghebremichael,1 and Sven Hoffner1

Department of Bacteriology, Swedish Institute for Infectious Disease Control,1 Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden,2 Department of Mycobacteriology, United Laboratory, Tartu University Clinics, Tartu,3 North-Estonian Regional Hospital, Tallinn, Estonia4

Received 28 January 2003/ Returned for modification 3 April 2003/ Accepted 19 June 2003

It is generally thought that there is full cross-resistance in Mycobacterium tuberculosis between the aminoglycoside drugs kanamycin and amikacin. However, kanamycin resistance and amikacin susceptibility were seen in 43 of 79 (54%) multidrug-resistant Estonian isolates, indicating that there might be a need to test the resistance of M. tuberculosis isolates to both drugs.

* Corresponding author. Mailing address: Tartu University Clinics, United Laboratory, Department of Mycobacteriology, Puusepa 1A, 50406 Tartu, Estonia. Phone: 3727 428 262. Fax: 3727 319 326. E-mail: annika.kruuner{at}kliinikum.ee.

Antimicrobial Agents and Chemotherapy, September 2003, p. 2971-2973, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.2971-2973.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Louw, G. E., Warren, R. M., Gey van Pittius, N. C., McEvoy, C. R. E., Van Helden, P. D., Victor, T. C. (2009). A Balancing Act: Efflux/Influx in Mycobacterial Drug Resistance. Antimicrob. Agents Chemother. 53: 3181-3189 [Full Text]  
  • Maus, C. E., Plikaytis, B. B., Shinnick, T. M. (2005). Molecular Analysis of Cross-Resistance to Capreomycin, Kanamycin, Amikacin, and Viomycin in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 49: 3192-3197 [Abstract] [Full Text]  


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