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Antimicrobial Agents and Chemotherapy, September 2003, p. 2974-2977, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.2974-2977.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Activity of Daptomycin against Recent North American Isolates of Streptococcus pneumoniae

M. I. Restrepo,1 J. A. Velez,1,{dagger} M. L. McElmeel,2 C. G. Whitney,3 and J. H. Jorgensen1,2*

Departments of Medicine,1 Pathology, University of Texas Health Science Center, San Antonio, Texas 78229,2 Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 303333

Received 26 March 2003/ Returned for modification 24 May 2003/ Accepted 23 June 2003

Daptomycin MICs at which 50% of isolates were inhibited (MIC50s) and MIC90s determined by the NCCLS broth microdilution method were both 0.25 µg/ml (range, 0.06 to 2 µg/ml) for 350 pneumococcal isolates. MICs determined by E test strips on commercially prepared Mueller-Hinton sheep blood agars with different calcium contents were 2 to 3 dilutions higher than those determined by strips that contained daptomycin plus calcium. Daptomycin zone diameters varied little on the same media.

* Corresponding author. Mailing address: Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Dr., San Antonio, TX 78229. Phone: (210) 567-4088. Fax: (210) 567-2367. E-mail: jorgensen{at}uthscsa.edu.

{dagger} Present address: Instituto de Ciencias de la Salud, Medellin, Colombia.

Antimicrobial Agents and Chemotherapy, September 2003, p. 2974-2977, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.2974-2977.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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