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Antimicrobial Agents and Chemotherapy, September 2003, p. 2984-2986, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.2984-2986.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Effects of 16S rRNA Gene Mutations on Tetracycline Resistance in Helicobacter pylori

Monique M. Gerrits, Marco Berning, Arnoud H. M. Van Vliet, Ernst J. Kuipers, and Johannes G. Kusters*

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands

Received 3 February 2003/ Returned for modification 12 May 2003/ Accepted 18 June 2003

The triple-base-pair 16S rDNA mutation AGA926-928->TTC mediates high-level tetracycline resistance in Helicobacter pylori. In contrast, single- and double-base-pair mutations mediated only low-level tetracycline resistance and decreased growth rates in the presence of tetracycline, explaining the preference for the TTC mutation in tetracycline-resistant H. pylori isolates.

* Corresponding author. Mailing address: Department of Gastroenterology and Hepatology, Rm. L459, Erasmus MC-University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. Phone: 31-10-4632982. Fax: 31-10-4632793. E-mail: j.g.kusters{at}erasmusmc.nl.

Antimicrobial Agents and Chemotherapy, September 2003, p. 2984-2986, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.2984-2986.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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