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Antimicrobial Agents and Chemotherapy, September 2003, p. 2993-2996, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.2993-2996.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Multiple Antibiotic Resistance Gene Transfer from Animal to Human Enterococci in the Digestive Tract of Gnotobiotic Mice

C. Moubareck,1 N. Bourgeois,1 P. Courvalin,2 and F. Doucet-Populaire1*

Laboratoire de Microbiologie, UFR de Sciences Pharmaceutiques et Biologiques, Université René Descartes, 75270 Paris Cedex 06,1 Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15, France2

Received 27 January 2003/ Returned for modification 2 April 2003/ Accepted 18 June 2003

It has been proposed that food animals represent the source of glycopeptide resistance genes present in enterococci from humans. We demonstrated the transfer of vanA and of other resistance genes from porcine to human Enterococcus faecium at high frequency in the digestive tract of gnotobiotic mice. Tylosin in the drinking water favored colonization by transconjugants.

* Corresponding author. Mailing address: Faculté des Sciences Pharmaceutiques et Biologiques, Laboratoire de Microbiologie, 4 Avenue de l'Observatoire, 75270 Paris Cedex 06, France. Phone: (33) 1 53 73 99 13. Fax: (33) 1 53 73 99 23. E-mail: fdp{at}pharmacie.univ-paris5.fr.

Antimicrobial Agents and Chemotherapy, September 2003, p. 2993-2996, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.2993-2996.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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