This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ul-Ain, Q.
Right arrow Articles by Khuller, G. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ul-Ain, Q.
Right arrow Articles by Khuller, G. K.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, September 2003, p. 3005-3007, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.3005-3007.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Chemotherapeutic Potential of Orally Administered Poly(Lactide-Co-Glycolide) Microparticles Containing Isoniazid, Rifampin, and Pyrazinamide against Experimental Tuberculosis

Qurrat ul-Ain, Sadhna Sharma, and G. K. Khuller*

Department of Biochemistry, Postgraduate Institute of Medical Education & Research, Chandigarh 160 012, India

Received 3 July 2002/ Returned for modification 24 September 2002/ Accepted 20 June 2003

Poly(lactide-co-glycolide) (PLG) microspheres (diameter, less than 3 µm) containing isoniazid, rifampin, and pyrazinamide were used in a sustained oral drug delivery system to treat murine tuberculosis. Drug levels above the MIC were observed up to 72 h in plasma and for 9 days in various organs. Relative bioavailability of encapsulated drugs was greater than that of free drugs. Chemotherapy results showed better or equivalent clearance of bacilli in the PLG-drug-administered group (weekly) than with free drugs (daily).

* Corresponding author. Mailing address: Department of Biochemistry, PGIMER, Chandigarh 160 012, India. Phone: 0172-747 585, ext. 5174-75. Fax: 0172-744 401, 745 078. E-mail: gkkhuller{at}yahoo.co.in.

Antimicrobial Agents and Chemotherapy, September 2003, p. 3005-3007, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.3005-3007.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Pandey, R., Khuller, G. K. (2004). Chemotherapeutic potential of alginate-chitosan microspheres as anti-tubercular drug carriers. J Antimicrob Chemother 53: 635-640 [Abstract] [Full Text]  
  • Pandey, R., Sharma, A., Zahoor, A., Sharma, S., Khuller, G. K., Prasad, B. (2003). Poly (DL-lactide-co-glycolide) nanoparticle-based inhalable sustained drug delivery system for experimental tuberculosis. J Antimicrob Chemother 52: 981-986 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»