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Antimicrobial Agents and Chemotherapy, September 2003, p. 3025-3029, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.3025-3029.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of a New Lipopeptide, HMR 1043, against Susceptible and Resistant Gram-Positive Isolates

Pascale Bemer,1* Marie-Emmanuelle Juvin,1 Andre Bryskier,2 and Henri Drugeon1

Department of Microbiology, Hôtel-Dieu University Hospital, Nantes,1 Clinical Pharmacology of Anti-Infectives, Aventis Pharma, Hoechst Marion Roussel, Romainville, France2

Received 18 March 2002/ Returned for modification 10 May 2002/ Accepted 6 June 2003

The purpose of this study was to compare the activity of HMR 1043 with those of daptomycin and teicoplanin against gram-positive isolates. Susceptibility tests were performed for 52 strains, 26 parental strains, including staphylococcal, streptococcal, enterococcal, and listerial strains, and 26 HMR 1043-resistant mutants obtained from parental strains by using the Szybalski method. Agar dilution and disk diffusion susceptibility tests were performed by the procedures outlined by the NCCLS. HMR 1043 demonstrated good activity against susceptible and resistant gram-positive bacteria. The activity of HMR 1043 in vitro was less influenced by the presence of calcium ions than that of daptomycin. Susceptibility test breakpoints were not defined because of the poor correlation coefficients obtained with the different disks tested.

* Corresponding author. Mailing address: Department of Microbiology, Hôtel-Dieu University Hospital, 9, Quai Moncousu, 44093 Nantes cedex 01, France. Phone: (33) 2 40 08 39 85. Fax: (33) 2 40 16 54 55. E-mail: pascale.bemer{at}chu-nantes.fr.

Antimicrobial Agents and Chemotherapy, September 2003, p. 3025-3029, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.3025-3029.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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