AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nishino, K.
Right arrow Articles by Yamaguchi, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nishino, K.
Right arrow Articles by Yamaguchi, A.
Antimicrobial Agents and Chemotherapy, September 2003, p. 3030-3033, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.3030-3033.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Roles of TolC-Dependent Multidrug Transporters of Escherichia coli in Resistance to ß-Lactams

Kunihiko Nishino,1,2,3,4 Junko Yamada,1,2,3 Hidetada Hirakawa,1,2,3 Takahiro Hirata,1,2,3 and Akihito Yamaguchi1,2,3*

Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki,1 CREST, Japan Science and Technology Corporation, Osaka 567-0047,2 Faculty of Pharmaceutical Science,3 Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan4

Received 10 March 2003/ Returned for modification 7 May 2003/ Accepted 18 June 2003

AcrAB exports some ß-lactam antibiotics in the periplasm out of cells via an outer-membrane channel, TolC. It has been reported that eight drug transporters in Escherichia coli cooperate with TolC. In this study, the roles of the drug exporters of E. coli in ß-lactam resistance were examined. We found that five of five resistance-nodulation-cell division-type drug exporters confer ß-lactam antibiotic resistance, while no other drug exporters confer any ß-lactam resistance even when they cooperate with TolC.

* Corresponding author. Mailing address: Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan. Phone: 81-6-6879-8545. Fax: 81-6-6879-8549. E-mail: akihito{at}sanken.osaka-u.ac.jp.

Antimicrobial Agents and Chemotherapy, September 2003, p. 3030-3033, Vol. 47, No. 9
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.9.3030-3033.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2003 by the American Society for Microbiology. All rights reserved.