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Antimicrobial Agents and Chemotherapy, January 2004, p. 319-322, Vol. 48, No. 1
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.1.319-322.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

FKS1 Mutations Responsible for Selective Resistance of Saccharomyces cerevisiae to the Novel 1,3-ß-Glucan Synthase Inhibitor Arborcandin C

Takao Ohyama,* Shunichi Miyakoshi, and Fujio Isono

Lead Discovery Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140-8710, Japan

Received 7 August 2003/ Returned for modification 11 September 2003/ Accepted 26 September 2003

Arborcandin C is a novel antibiotic with potent antifungal activity that inhibits 1,3-ß-glucan synthase in fungi. We examined spontaneous Saccharomyces cerevisiae mutants which are selectively resistant to arborcandin C and revealed that a single amino acid replacement in Fks1p of Asn470 with Lys or of Leu642 with Ser confers selective resistance on Fks1p mutants.

* Corresponding author. Mailing address: Lead Discovery Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. Phone: 81-3-3492-3131. Fax: 81-3-5436-8578. E-mail: takaoo{at}shina.sankyo.co.jp.

Antimicrobial Agents and Chemotherapy, January 2004, p. 319-322, Vol. 48, No. 1
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.1.319-322.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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