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Antimicrobial Agents and Chemotherapy, January 2004, p. 344-347, Vol. 48, No. 1
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.1.344-347.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Comparison of In Vitro Activities of Ketolides, Macrolides, and an Azalide against the Spirochete Borrelia burgdorferi

Institute of Medical Microbiology, University Hospital of Frankfurt, D-60596 Frankfurt/Main,¹ Department of Biological Electron Microscopy, University of Bayreuth, D-95440 Bayreuth, Germany²

Received 13 March 2003/ Returned for modification 3 June 2003/ Accepted 2 October 2003

Two ketolides, three macrolides, and one azalide were tested in vitro against 17 isolates of the B. burgdorferi s.l. complex. As measured in micrograms per milliliter, activity was highest for cethromycin (MIC at which 90% of the tested isolates were inhibited [MIC₉₀], 0.0019 µg/ml) and telithromycin (MIC₉₀, 0.0078 µg/ml). Electron-microscope analysis and time-kill studies also supported enhanced effectiveness of both ketolides.

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