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Antimicrobial Agents and Chemotherapy, October 2004, p. 3715-3719, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.3715-3719.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Antifungal Therapy of Murine Aspergillus terreus Infection

John R. Graybill,1 Steve Hernandez,1 Rosie Bocanegra,1 and Laura K. Najvar1*

The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, San Antonio, Texas1

Received 19 March 2004/ Returned for modification 24 April 2004/ Accepted 20 June 2004

Aspergillus terreus is a species which is being seen increasingly frequently and which is highly resistant to amphotericin B in vitro and clinically. We evaluated amphotericin B, caspofungin, and posaconazole in a murine model of acute invasive aspergillosis. Caspofungin and posaconazole both appeared beneficial and may be reasonable treatment alternatives for infection with A. terreus.

* Corresponding author. Mailing address: The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases (mail code 7881), 7703 Floyd Curl Dr., San Antonio, TX 78229-3900. Phone: (210) 567-0990. Fax: (210) 567-0962. E-mail: Najvar{at}uthscsa.edu.

Antimicrobial Agents and Chemotherapy, October 2004, p. 3715-3719, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.3715-3719.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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