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Antimicrobial Agents and Chemotherapy, October 2004, p. 3996-4001, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.3996-4001.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Mechanisms of Resistance in Multiple-Antibiotic-Resistant Escherichia coli Strains of Human, Animal, and Food Origins

Yolanda Sáenz,1 Laura Briñas,1 Elena Domínguez,1 Joaquim Ruiz,2 Myriam Zarazaga,1 Jordi Vila,2 and Carmen Torres*1

Área Bioquímica y Biología Molecular, Universidad de La Rioja, Logroño,1 Servei de Microbiología, Institut Clínic d'Infeccions i Immunología, IDIBAPS, Hospital Clínic, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain2

Received 3 March 2004/ Returned for modification 21 April 2004/ Accepted 1 June 2004

Seventeen multiple-antibiotic-resistant nonpathogenic Escherichia coli strains of human, animal, and food origins showed a wide variety of antibiotic resistance genes, many of them carried by class 1 and class 2 integrons. Amino acid changes in MarR and mutations in marO were identified for 15 and 14 E. coli strains, respectively.


* Corresponding author. Mailing address: Área Bioquímica y Biología Molecular, Universidad de La Rioja, Madre de Dios 51, 26006 Logroño, Spain. Phone: 34-941-299750. Fax: 34-941-299721. E-mail: carmen.torres{at}daa.unirioja.es.


Antimicrobial Agents and Chemotherapy, October 2004, p. 3996-4001, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.3996-4001.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.




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