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Antimicrobial Agents and Chemotherapy, October 2004, p. 4002-4005, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.4002-4005.2004

Determination of Susceptibilities of 26 Leptospira sp. Serovars to 24 Antimicrobial Agents by a Broth Microdilution Technique

Clinton K. Murray and Duane R. Hospenthal*

Infectious Disease Service, Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas

Received 7 April 2004/ Returned for modification 6 June 2004/ Accepted 23 June 2004

The MICs of 24 antimicrobials for 26 Leptospira spp. serovars were determined using a broth microdilution technique. The MICs at which 90% of isolates tested were inhibited (MIC90s) of cefepime, imipenem-cilastatin, erythromycin, clarithromycin, and telithromycin were all ≤0.01 µg/ml. The MIC90s of amoxicillin, aztreonam, cefdinir, chloramphenicol, and penicillin G were ≥3.13 µg/ml. Many antimicrobials have excellent in vitro activity against Leptospira.

* Corresponding author. Mailing address: Infectious Disease (MCHE-MDI), Brooke Army Medical Center, 3851 Roger Brooke Dr., Fort Sam Houston, TX 78234. Phone: (210) 916-4355. Fax: (210) 916-0388. E-mail: Duane.Hospenthal{at}amedd.army.mil.

Antimicrobial Agents and Chemotherapy, October 2004, p. 4002-4005, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.4002-4005.2004




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