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Antimicrobial Agents and Chemotherapy, October 2004, p. 4009-4011, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.4009-4011.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Correlation between In Vitro Susceptibility of Scedosporium apiospermum to Voriconazole and In Vivo Outcome of Scedosporiosis in Guinea Pigs

Javier Capilla and Josep Guarro*

Unitat de Microbiologia Facultat de Medicina, Universitat Rovira i Virgili, Reus, Spain

Received 1 September 2003/ Returned for modification 15 October 2003/ Accepted 28 May 2004

We have evaluated the efficacy of voriconazole (VRC) in a systemic infection by Scedosporium apiospermum in immunodepressed guinea pigs. Animals were infected with two strains; one required a VRC MIC of 0.5 to 1 µg/ml, common for this fungus, and the other required a high MIC (8 µg/ml), unusual in this species. VRC prolonged survival and reduced fungal load in kidney and brain tissues of the animals infected with the first strain but was unable to prolong survival or to reduce fungal load in brain tissue for the latter strain.

* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201 Reus, Spain. Phone: 977 759359. Fax: 977 759322. E-mail: jga{at}fmcs.urv.es.

Antimicrobial Agents and Chemotherapy, October 2004, p. 4009-4011, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.4009-4011.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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