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Antimicrobial Agents and Chemotherapy, October 2004, p. 4033-4036, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.4033-4036.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Antistaphylococcal Activity of LBM415, a New Peptide Deformylase Inhibitor, Compared with Those of Other Agents

Kim Credito, Gengrong Lin, Lois M. Ednie, and Peter C. Appelbaum*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania

Received 4 June 2004/ Returned for modification 30 June 2004/ Accepted 1 July 2004

The MICs of LBM415, a new peptide diformylase inhibitor, were ≤0.06 to 4.0 µg/ml for 258 isolates of Staphylococcus aureus and coagulase-negative staphylococci. LBM415 MICs were similar irrespective of whether the strains were methicillin susceptible or resistant. All strains were also susceptible to vancomycin, linezolid, ranbezolid, daptomycin, oritavancin, and quinupristin-dalfopristin. LBM415 at the MIC was bacteriostatic after 24 h.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

Antimicrobial Agents and Chemotherapy, October 2004, p. 4033-4036, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.4033-4036.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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