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Antimicrobial Agents and Chemotherapy, October 2004, p. 4037-4039, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.4037-4039.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Antistaphylococcal Activity of CB-181963 (CAB-175), an Experimental Parenteral Cephalosporin

Dianne B. Hoellman, Glenn A. Pankuch, and Peter C. Appelbaum*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania

Received 23 April 2004/ Accepted 21 June 2004

Among 265 methicillin-susceptible and -resistant staphylococci, CB-181963 (CAB-175) had a 50% minimum inhibitory concentration of 2 µg/ml and a 90% minimum inhibitory concentration of 4 µg/ml. All strains except two vancomycin-resistant S. aureus and 5 vancomycin-intermediate S. aureus strains were also susceptible to vancomycin and teicoplanin, and all were susceptible to linezolid, ranbezolid, tigecycline, and quinupristin-dalfopristin. Most methicillin-resistant strains were levofloxacin resistant. CB-181963 was bactericidal against all six methicillin-resistant strains at four times the MIC after 24 h.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

Antimicrobial Agents and Chemotherapy, October 2004, p. 4037-4039, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.4037-4039.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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