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Antimicrobial Agents and Chemotherapy, October 2004, p. 4042-4046, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.4042-4046.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

CARB-9, a Carbenicillinase Encoded in the VCR Region of Vibrio cholerae Non-O1, Non-O139 Belongs to a Family of Cassette-Encoded ß-Lactamases

Alejandro Petroni,^1, Roberto G. Melano,^1,2, Héctor A. Saka,¹ Alicia Garutti,¹ Laura Mange,¹ Fernando Pasterán,¹ Melina Rapoport,¹ Mariana Miranda,¹ Diego Faccone,¹ Alicia Rossi,^1, Paul S. Hoffman,² and Marcelo F. Galas^1*

Servicio Antimicrobianos, Dpto. Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán," Buenos Aires, Argentina,¹ Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada²

Received 11 September 2003/ Returned for modification 15 December 2003/ Accepted 31 May 2004

The gene bla_CARB-9 was located in the Vibrio cholerae super-integron, but in a different location relative to bla_CARB-7. CARB-9 (pI 5.2) conferred ß-lactam MICs four to eight times lower than those conferred by CARB-7, differing at Ambler's positions V97I, L124F, and T228K. Comparison of the genetic environments of all reported bla_CARB genes indicated that the CARB enzymes constitute a family of cassette-encoded ß-lactamases.

This work is dedicated to the memory of our dear Ali.

A.P. and R.G.M. contributed equally to this work.

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