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Antimicrobial Agents and Chemotherapy, October 2004, p. 4050-4053, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.4050-4053.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

AmpC ß-Lactamase in an Escherichia coli Clinical Isolate Confers Resistance to Expanded-Spectrum Cephalosporins

Hedi Mammeri,1 Hasan Nazic,1,2 Thierry Naas,1 Laurent Poirel,1 Sophie Léotard,1 and Patrice Nordmann1*

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, Le Kremlin-Bicêtre, France,1 Department of Microbiology, Faculty of Medicine, Istanbul University, Istanbul, Turkey2

Received 5 February 2004/ Returned for modification 14 April 2004/ Accepted 26 June 2004

Cloning, sequencing, and biochemical analysis identified a novel AmpC-type ß-lactamase conferring resistance to extended-spectrum cephalosporins in an Escherichia coli clinical isolate. This enzyme, exhibiting 14 amino acid substitutions compared to a reference AmpC cephalosporinase of E. coli, hydrolyzed ceftazidime and cefepime significantly.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France. Phone: 33 1 45 21 36 32. Fax: 33 1 45 21 63 40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, October 2004, p. 4050-4053, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.4050-4053.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Jacoby, G. A. (2009). AmpC {beta}-Lactamases. Clin. Microbiol. Rev. 22: 161-182 [Abstract] [Full Text]  
  • Mammeri, H., Eb, F., Berkani, A., Nordmann, P. (2008). Molecular characterization of AmpC-producing Escherichia coli clinical isolates recovered in a French hospital. J Antimicrob Chemother 61: 498-503 [Abstract] [Full Text]  
  • Hee Lee, S., Lee, J. H., Heo, M. J., Bae, I. K., Jeong, S. H., Cha, S.-S., Wachino, J.-i., Arakawa, Y. (2007). Exact Location of the Region Responsible for the Extended Substrate Spectrum in Class C {beta}-Lactamases. Antimicrob. Agents Chemother. 51: 3778-3779 [Full Text]  
  • Mammeri, H., Poirel, L., Nordmann, P. (2007). Extension of the hydrolysis spectrum of AmpC {beta}-lactamase of Escherichia coli due to amino acid insertion in the H-10 helix. J Antimicrob Chemother 60: 490-494 [Abstract] [Full Text]  
  • Mammeri, H., Poirel, L., Fortineau, N., Nordmann, P. (2006). Naturally Occurring Extended-Spectrum Cephalosporinases in Escherichia coli.. Antimicrob. Agents Chemother. 50: 2573-2576 [Abstract] [Full Text]  


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