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Antimicrobial Agents and Chemotherapy, October 2004, p. 4056-4058, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.4056-4058.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Sequential Therapy with Caspofungin and Fluconazole for Candida albicans Infection

Francesco Barchiesi,1* Elisabetta Spreghini,1 Isabella Baldassarri,1 Anna Marigliano,1 Daniela Arzeni,1 Daniele Giannini,2 and Giorgio Scalise1

Istituto di Malattie Infettive e Medicina Pubblica,1 Centro di Gestione Presidenza Medicina e Chirurgia, Università Politecnica delle Marche, Ancona, Italy2

Received 11 June 2004/ Accepted 18 June 2004

A sequential therapy of caspofungin (CAS) and fluconazole (FLC) administration for treatment of Candida albicans infection was investigated. Treatment with CAS followed by FLC was as effective as CAS treatment given alone for the same duration. Our data suggest that switching from CAS to FLC is a potentially explorable therapeutic option for treatment of systemic candidiasis.

* Corresponding author. Mailing address: Istituto di Malattie Infettive e Medicina Pubblica, Università Politecnica delle Marche, Azienda Ospedaliera Umberto I, Via Conca, 60020, Torrette di Ancona, Ancona, Italy. Phone: 39.0715963467. Fax: 39.0715963468. E-mail: l.infettive{at}ao-umbertoprimo.marche.it.

Antimicrobial Agents and Chemotherapy, October 2004, p. 4056-4058, Vol. 48, No. 10
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.10.4056-4058.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Spreghini, E., Maida, C. M., Milici, M. E., Scalise, G., Barchiesi, F. (2008). Posaconazole Activity against Candida glabrata after Exposure to Caspofungin or Amphotericin B. Antimicrob. Agents Chemother. 52: 513-517 [Abstract] [Full Text]  


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