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Antimicrobial Agents and Chemotherapy, November 2004, p. 4246-4249, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4246-4249.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Concentrations of Gemifloxacin at the Target Site in Healthy Volunteers after a Single Oral Dose

Florian Islinger,1 Rene Bouw,2 Mathias Stahl,2 Edith Lackner,1 Petra Zeleny,1 Martin Brunner,1 Markus Müller,1 Hans Georg Eichler,1 and Christian Joukhadar1,3*

Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics,1 Institute of Pharmacology, Medical University of Vienna, Vienna, Austria,3 GlaxoSmithKline, Greenford, United Kingdom2

Received 15 April 2004/ Returned for modification 24 May 2004/ Accepted 20 July 2004

Free gemifloxacin concentrations in the interstitial space fluid of skeletal muscle and subcutaneous adipose tissue were measured by means of in vivo microdialysis to characterize the ability of gemifloxacin to penetrate human soft tissues. Twelve healthy volunteers received a single oral dose of 320 mg of gemifloxacin. The mean areas under the concentration-time curves from 0 to 10 h (AUC0-10) were significantly higher for soft tissue than for unbound gemifloxacin in plasma (P < 0.05). The ratios of the mean AUC0-10 for tissue to the AUC0-10 for free gemifloxacin in plasma were 1.7 ± 0.7 (mean ± standard deviation) for skeletal muscle and 2.4 ± 1.0 for adipose tissue. The AUC0-24 ratios for free gemifloxacin in tissues to the MIC at which 90% of frequently isolated bacteria are inhibited were close to or higher than 100 h. Therefore, based on pharmacokinetic and pharmacodynamic calculations, we conclude that gemifloxacin might be a useful therapeutic option for the treatment of soft tissue infections.

* Corresponding author. Mailing address: Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, Medical University of Vienna, Allgemeines Krankenhaus, Waehringer Guertel 18-20, 1090 Vienna, Austria. Phone: 43-1-40400-2981. Fax: 43-1-40400-2998. E-mail: christian.joukhadar{at}meduniwien.ac.at.

Antimicrobial Agents and Chemotherapy, November 2004, p. 4246-4249, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4246-4249.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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