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Antimicrobial Agents and Chemotherapy, November 2004, p. 4427-4429, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4427-4429.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Evidence for Biliary Excretion of Vancomycin into Stool during Intravenous Therapy: Potential Implications for Rectal Colonization with Vancomycin-Resistant Enterococci

Brian P. Currie1* and Luciano Lemos-Filho2

Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center,1 Albert Einstein College of Medicine, Bronx, New York2

Received 24 March 2004/ Returned for modification 28 April 2004/ Accepted 11 July 2004

Sixty-three stool samples and five bile samples were prospectively collected from 33 patients receiving intravenous vancomycin therapy and were quantitatively analyzed for vancomycin by a competitive immunoassay. Vancomycin was excreted via bile into the stools of almost all patients at concentrations of 3.3 to 94.8 µg/ml after ≥5 days of a therapy of 1 g every 12 h.

* Corresponding author. Mailing address: Montefiore Medical Center, 111 E. 210th St., Bronx, NY 10467. Phone: (718) 920-6078. Fax: (718) 920-8543. E-mail: bcurrie{at}montefiore.org.

Antimicrobial Agents and Chemotherapy, November 2004, p. 4427-4429, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4427-4429.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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