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Antimicrobial Agents and Chemotherapy, November 2004, p. 4435-4437, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4435-4437.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Community-Onset Disease Caused by Citrobacter freundii Producing a Novel CTX-M ß-Lactamase, CTX-M-30, in Canada

Department of Medical Microbiology and Immunology, Center for Research in Antiinfectives & Biotechnology, Creighton University School of Medicine, Omaha, Nebraska,¹ Division of Microbiology, Calgary Laboratory Services, and Department of Pathology & Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada²

Received 12 March 2004/ Returned for modification 23 May 2004/ Accepted 15 July 2004

Strains of Citrobacter freundii intermediate to cefotaxime but sensitive to ceftazidime were isolated from four different patients in Canada. Sequencing of PCR products by use of CTX-M-specific primers revealed a new combination of four amino acid substitutions. This new gene was designated bla_CTX-M-30 and was encoded on a 3-kb plasmid. The pI of CTX-M-30 was 8.0.

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