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Antimicrobial Agents and Chemotherapy, November 2004, p. 4438-4440, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4438-4440.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Plasmid-Mediated Carbapenem-Hydrolyzing Enzyme KPC-2 in an Enterobacter sp.

Ashfaque Hossain,1,2 M. J. Ferraro,3 R. M. Pino,3 R. B. Dew III,3 E. S. Moland,1,2 T. J. Lockhart,1,2 K. S. Thomson,1,2 R. V. Goering,2 and N. D. Hanson1,2*

Center for Research in Anti-Infectives and Biotechnology,1 Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska,2 Massachusetts General Hospital, Boston, Massachusetts3

Received 12 February 2004/ Returned for modification 16 May 2004/ Accepted 6 July 2004

A strain of an Enterobacter sp. with reduced susceptibility to imipenem, which produced a plasmid-mediated class A carbapenem-hydrolyzing enzyme, KPC-2 ß-lactamase, was isolated from a patient with sepsis at a Boston hospital. This is the first report of the production of a plasmid-encoded KPC-2 ß-lactamase by an Enterobacter sp.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178. Phone: (402) 280-5837. Fax: (402) 280-1875. E-mail: ndhanson{at}creighton.edu.

Antimicrobial Agents and Chemotherapy, November 2004, p. 4438-4440, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4438-4440.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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