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Plasmid-Mediated Carbapenem-Hydrolyzing Enzyme KPC-2 in an Enterobacter sp.

Center for Research in Anti-Infectives and Biotechnology,¹ Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska,² Massachusetts General Hospital, Boston, Massachusetts³

Received 12 February 2004/ Returned for modification 16 May 2004/ Accepted 6 July 2004

A strain of an Enterobacter sp. with reduced susceptibility to imipenem, which produced a plasmid-mediated class A carbapenem-hydrolyzing enzyme, KPC-2 ß-lactamase, was isolated from a patient with sepsis at a Boston hospital. This is the first report of the production of a plasmid-encoded KPC-2 ß-lactamase by an Enterobacter sp.

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