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Antimicrobial Agents and Chemotherapy, November 2004, p. 4441-4443, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4441-4443.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Altered Susceptibility of Candida glabrata Bloodstream Isolates to Triazoles at Clinically Relevant pH Values: Comparison of the NCCLS M27-A2, Sensititre YeastOne, and Etest Methods

Manjunath P. Pai* and Ariel L. Jones

College of Pharmacy, University of New Mexico, Albuquerque, New Mexico

Received 20 April 2004/ Returned for modification 8 June 2004/ Accepted 20 July 2004

We studied the MICs of triazoles against 15 Candida glabrata clinical isolates by the NCCLS M27-A2, Sensititre YeastOne, and Etest methods by using media at pHs 6.0, 7.0, and 7.4. Thirteen isolates were less susceptible to triazoles at pH 6.0 and more susceptible to triazoles at pH 7.4 compared to pH 7.0.

* Corresponding author. Mailing address: College of Pharmacy, MSC09 5360, 1 University of New Mexico, Albuquerque, NM 87131-0001. Phone: (505) 272-8931. Fax: (505) 272-6749. E-mail: apai{at}salud.unm.edu.

Antimicrobial Agents and Chemotherapy, November 2004, p. 4441-4443, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4441-4443.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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