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Antimicrobial Agents and Chemotherapy, November 2004, p. 4447-4449, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4447-4449.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Novel Mutations within the embB Gene in Ethambutol-Susceptible Clinical Isolates of Mycobacterium tuberculosis

Division of Medical Sciences, National Cancer Centre,¹ Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore²

Received 30 March 2004/ Returned for modification 10 May 2004/ Accepted 15 July 2004

Genetic analysis of the embB gene revealed mutations in 17 (68%) of 25 ethambutol (EMB) resistant isolates (M306I, M306V, M306L, Q497R) but also in 4 (20%) of 20 EMB-susceptible isolates of Mycobacterium tuberculosis, namely, an ATGATM substitution resulting in M306I, G406N, and the novel alterations M423I and A659T.

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