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Antimicrobial Agents and Chemotherapy, November 2004, p. 4466-4469, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4466-4469.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

SHV-49, a Novel Inhibitor-Resistant ß-Lactamase in a Clinical Isolate of Klebsiella pneumoniae

Véronique Dubois,1* Laurent Poirel,2 Corinne Arpin,1 Laure Coulange,1 Cécile Bebear,3 Patrice Nordmann,2 and Claudine Quentin1

Laboratoire de Microbiologie, Faculté de Pharmacie, Université de Bordeaux 2,1 Laboratoire de Bactériologie, Hôpital Pellegrin, Bordeaux,3 Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre cedex, France2

Received 28 January 2004/ Returned for modification 2 May 2004/ Accepted 11 July 2004

A clinical strain of Klebsiella pneumoniae carried the blaSHV-49 gene, encoding a novel inhibitor-resistant ß-lactamase of pI 7.6, derived from SHV-1 by the single substitution M69I. It also harbored a gene differing from blaSHV-11 by four silent mutations and coding for a penicillinase. Both genes were chromosome located and might represent either a species-specific gene or an acquired resistance gene.

* Corresponding author. Mailing address: Laboratoire de Microbiologie, Faculté de Pharmacie, Université de Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Phone: 33 5 57 57 10 75. Fax: 33 5 56 90 90 72. E-mail: veronique.dubois{at}bacterio.u-bordeaux2.fr.

Antimicrobial Agents and Chemotherapy, November 2004, p. 4466-4469, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4466-4469.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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