AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lee, L. S.
Right arrow Articles by Paton, N. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lee, L. S.
Right arrow Articles by Paton, N. I.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, November 2004, p. 4476-4478, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4476-4478.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Pharmacokinetics of Indinavir at 800, 600, and 400 Milligrams Administered with Ritonavir at 100 Milligrams and Efavirenz in Ethnic Chinese Patients Infected with Human Immunodeficiency Virus

Lawrence S. Lee,* Anushia Panchalingam, Marline C. Yap, and Nicholas I. Paton

Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Republic of Singapore

Received 8 April 2004/ Returned for modification 14 June 2004/ Accepted 11 July 2004

We assessed the pharmacokinetics of three different doses of indinavir in five patients. All doses achieved trough concentrations above efficacy thresholds. Toxic trough concentrations were observed in all patients receiving 800 mg, in two patients receiving 600 mg, and in none receiving 400 mg. Indinavir at 400 mg may be efficacious and less toxic in patients taking ritonavir and efavirenz.

* Corresponding author. Mailing address: Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, 600 N. Wolfe St., Osler 527, Baltimore, MD 21287. Phone: (410) 955-3100. Fax: (410) 614-9978. E-mail: llee3{at}jhsph.edu.

Antimicrobial Agents and Chemotherapy, November 2004, p. 4476-4478, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4476-4478.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2004 by the American Society for Microbiology. All rights reserved.