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Antimicrobial Agents and Chemotherapy, November 2004, p. 4476-4478, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4476-4478.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Pharmacokinetics of Indinavir at 800, 600, and 400 Milligrams Administered with Ritonavir at 100 Milligrams and Efavirenz in Ethnic Chinese Patients Infected with Human Immunodeficiency Virus

Lawrence S. Lee,* Anushia Panchalingam, Marline C. Yap, and Nicholas I. Paton

Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Republic of Singapore

Received 8 April 2004/ Returned for modification 14 June 2004/ Accepted 11 July 2004

We assessed the pharmacokinetics of three different doses of indinavir in five patients. All doses achieved trough concentrations above efficacy thresholds. Toxic trough concentrations were observed in all patients receiving 800 mg, in two patients receiving 600 mg, and in none receiving 400 mg. Indinavir at 400 mg may be efficacious and less toxic in patients taking ritonavir and efavirenz.

* Corresponding author. Mailing address: Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, 600 N. Wolfe St., Osler 527, Baltimore, MD 21287. Phone: (410) 955-3100. Fax: (410) 614-9978. E-mail: llee3{at}jhsph.edu.

Antimicrobial Agents and Chemotherapy, November 2004, p. 4476-4478, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4476-4478.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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