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Antimicrobial Agents and Chemotherapy, November 2004, p. 4479-4481, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4479-4481.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Activity of Tigecycline (GAR-936) against Acinetobacter baumannii Strains, Including Those Resistant to Imipenem

María Eugenia Pachón-Ibáñez,1* Manuel Enrique Jiménez-Mejías,1 Cristina Pichardo,1 Ana Cristina Llanos,2 and Jerónimo Pachón1

Infectious Diseases Service,1 Microbiology Service, Virgen del Rocío University Hospitals, Seville, Spain2

Received 9 May 2004/ Returned for modification 9 June 2004/ Accepted 1 August 2004

We determined the in vitro activities of tigecycline and imipenem against 49 isolates of Acinetobacter baumannii, including those resistant to imipenem. The MIC at which 50% of the isolates were inhibited (MIC50) and the MIC90 for tigecycline and imipenem were 2 and 2 mg/liter and 32 and 128 mg/liter, respectively, with 92 and 20%, respectively, of the strains being susceptible. Tigecycline did not show bactericidal activity in the time-kill studies (n = 9 strains). Imipenem showed bactericidal activity against seven out of nine strains. These in vitro results show that tigecycline has good in vitro bacteriostatic activity against A. baumannii, including strains resistant to imipenem.

* Corresponding author. Mailing address: Servicio de Enfermedades Infecciosas, Hospitales Universitarios Virgen del Rocío, Avda. Manuel Siurot s/n, 41013 Seville, Spain. Phone: 34 955012376. Fax: 34 955012377. E-mail: menia{at}telefonica.net.

Antimicrobial Agents and Chemotherapy, November 2004, p. 4479-4481, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4479-4481.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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