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Antimicrobial Agents and Chemotherapy, November 2004, p. 4482-4484, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4482-4484.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Pharmacodynamics of Ceftazidime plus the Serine ß-Lactamase Inhibitor AM-112 against Escherichia coli Containing TEM-1 and CTX-M-1 ß-Lactamases

Karen E. Bowker,* Alan R. Noel, Timothy R. Walsh, Chris A. Rogers, and Alasdair P. MacGowan

Bristol Centre for Antimicrobial Research & Evaluation, North Bristol NHS Trust and University of Bristol, Bristol, United Kingdom

Received 15 January 2004/ Returned for modification 26 April 2004/ Accepted 20 July 2004

A strain of Escherichia coli containing TEM-1 and CTX-M-1 was tested in an in vitro pharmacokinetic model against ceftazidime with and without AM-112, a serine ß-lactamase inhibitor. Ceftazidime alone was less effective than ceftazidime plus AM-112, and a single dose was more effective than three fractionated doses.

* Corresponding author. Mailing address: Bristol Centre for Antimicrobial Research & Evaluation, North Bristol NHS Trust, Department of Medical Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol, BS10 5NB United Kingdom. Phone: 0044 (0) 1179595654. Fax: 0044 (0) 1179593217. E-mail: karen.bowker{at}north-bristol.swest.nhs.uk.

Antimicrobial Agents and Chemotherapy, November 2004, p. 4482-4484, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4482-4484.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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