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Antimicrobial Agents and Chemotherapy, November 2004, p. 4488-4490, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4488-4490.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Comparison of Simultaneous Splenic Sample PCR with Blood Sample PCR for Diagnosis and Treatment of Experimental Ehrlichia canis Infection

Shimon Harrus,1* Martin Kenny,2 Limor Miara,1 Itzhak Aizenberg,1 Trevor Waner,3 and Susan Shaw2

School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot,1 Israel Institute for Biological Research, Ness Ziona, Israel,3 Department of Clinical Veterinary Science, University of Bristol, Langford, Somerset, United Kingdom2

Received 17 March 2004/ Returned for modification 15 June 2004/ Accepted 26 July 2004

This report presents evidence that dogs recover from acute canine monocytic ehrlichiosis (CME) after 16 days of doxycycline treatment (10 mg/kg of body weight every 24 h). Blood PCR was as valuable as splenic aspirate PCR for early diagnosis of acute CME. Splenic aspirate PCR was, however, superior to blood PCR for the evaluation of ehrlichial elimination.

* Corresponding author. Mailing address: School of Veterinary Medicine, Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel. Phone: 972-3-9688546. Fax: 972-3-9604079. E-mail: harrus{at}agri.huji.ac.il.

Antimicrobial Agents and Chemotherapy, November 2004, p. 4488-4490, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4488-4490.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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