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Antimicrobial Agents and Chemotherapy, December 2004, p. 4873-4877, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4873-4877.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

ß-Lactamase Gene Expression in a Penicillin-Resistant Bacillus anthracis Strain

Yahua Chen,1 Fred C. Tenover,2 and Theresa M. Koehler1*

Department of Microbiology and Molecular Genetics, The University of Texas—Houston Health Science Center Medical School, Houston, Texas,1 Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia2

Received 6 April 2004/ Returned for modification 16 June 2004/ Accepted 13 August 2004

Expression of the bla1 and bla2 genes in an archetypal Bacillus anthracis strain is insufficient for penicillin resistance. In a penicillin-resistant clinical isolate, both genes are highly transcribed, but bla1 is the major contributor to high-level resistance to ampicillin. Differential expression of the bla genes is dependent upon strain background.

* Corresponding author. Mailing address: Department of Microbiology and Molecular Genetics, University of Texas—Houston Medical School, 6431 Fannin St., JFB 1.765, Houston, TX 77030. Phone: (713) 500-5450. Fax: (713) 500-5499. E-mail: theresa.m.koehler{at}uth.tmc.edu.

Antimicrobial Agents and Chemotherapy, December 2004, p. 4873-4877, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4873-4877.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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