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Antimicrobial Agents and Chemotherapy, December 2004, p. 4878-4881, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4878-4881.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Glucocorticoids Increase In Vitro and In Vivo Activities of Antibiotics against Chlamydophila pneumoniae

Dario Caronzolo, Valeria Lucini, Marilou Pannacci, Silvia Grosso, Federica Colleoni, Franco Fraschini, and Francesco Scaglione*

Department of Pharmacology, Chemotherapy, and Toxicology, University of Milan, Milan, Italy

Received 30 April 2004/ Returned for modification 19 July 2004/ Accepted 18 August 2004

The in vitro and in vivo antichlamydial activities of dexamethasone and beclomethasone alone and in combination with an antibiotic were tested. In vitro, dexamethasone and beclomethasone decreased the number of inclusion-forming units versus the control number (P < 0.001). The combination of glucocorticoids with azithromycin, telithromycin, or levofloxacin was more active than antibiotics used alone (P < 0.001). The combination, tested in a murine Chlamydophila pneumoniae infection model, produced similar results.

* Corresponding author. Mailing address: Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Via Vanvitelli no. 32, 20129 Milan, Italy. Phone: 39/0250317073. Fax: 39/0250317050. E-mail: francesco.scaglione{at}unimi.it.

Antimicrobial Agents and Chemotherapy, December 2004, p. 4878-4881, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4878-4881.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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