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Antimicrobial Agents and Chemotherapy, December 2004, p. 4889-4891, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4889-4891.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Effects of a Number of Classes of 50S Inhibitors on Stop Codon Readthrough during Protein Synthesis

Jill Thompson,1* Catherine A. Pratt,2 and Albert E. Dahlberg1

Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island,1 Department of Biochemistry, University of Bristol, Bristol, United Kingdom2

Received 22 July 2004/ Returned for modification 23 August 2004/ Accepted 29 August 2004

The effect of a number of antibiotics on stop codon readthrough during protein synthesis in Escherichia coli was examined. Inhibitors which bind close to the entrance of the peptide exit tunnel on the 50S ribosomal subunit promote substantial levels of readthrough, presumably by disrupting the mechanism of peptide release.

* Corresponding author. Mailing address: 69 Brown St., Providence, RI 02912. Phone: (401) 863-3652. Fax: (401) 863-1182. E-mail: Jill_Rosemary_Thompson{at}brown.edu.

Antimicrobial Agents and Chemotherapy, December 2004, p. 4889-4891, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4889-4891.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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