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Antimicrobial Agents and Chemotherapy, December 2004, p. 4895-4897, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4895-4897.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Chromosome-Encoded CTX-M-3 from Kluyvera ascorbata: a Possible Origin of Plasmid-Borne CTX-M-1-Derived Cefotaximases

María Margarita Rodríguez,1 Pablo Power,1 Marcela Radice,1 Carlos Vay,2 Angela Famiglietti,2 Moreno Galleni,3 Juan A. Ayala,4 and Gabriel Gutkind1*

Cátedra de Microbiología,1 Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina,2 Centro de Biología Molecular "Severo Ochoa," CSIC-UAM, Campus de Cantoblanco, Madrid, Spain,4 Centre d'Ingéniérie des Protéines, Institut de Chimie, Université de Liège, Sart Tilman, Belgium3

Received 23 March 2004/ Returned for modification 3 June 2004/ Accepted 19 August 2004

A gene identical to plasmid-borne blaCTX-M-3 is present in the chromosome of one Kluyvera ascorbata strain. It is associated with a structure including an inverted repeat right and an open reading frame 477-like gene probably involved in the mobilization of blaCTX-M-3. Two other K. ascorbata strains rendered the previously described blaKLUA-9 gene.

* Corresponding author. Mailing address: Cátedra de Microbiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 954 (1113), Buenos Aires, Argentina. Phone: 54 11 4964 8285. Fax: 0054 11 4508 3645. E-mail: ggutkind{at}ffyb.uba.ar.

Antimicrobial Agents and Chemotherapy, December 2004, p. 4895-4897, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4895-4897.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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