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Antimicrobial Agents and Chemotherapy, December 2004, p. 4898-4902, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4898-4902.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of OPT-80 and Comparator Drugs against Intestinal Bacteria

Sydney M. Finegold,1,2,3,4* Denise Molitoris,2 Marja-Liisa Vaisanen,2 Yuli Song,2 Chengxu Liu,2 and Mauricio Bolaños2

Medical,1 Research Services, VA Greater Los Angeles Healthcare System,2 Departments of Medicine,3 Microbiology, Immunology and Molecular Genetics, UCLA School of Medicine, Los Angeles, California4

Received 4 July 2004/ Returned for modification 28 July 2004/ Accepted 31 August 2004

The activities of OPT-80 against 453 intestinal bacteria were compared with those of seven other drugs. OPT-80 showed good activity against most clostridia, staphylococci, and enterococci, but streptococci, aerobic and facultative gram-negative rods, anaerobic gram-negative rods, and Clostridium ramosum were resistant. Poor activity against anaerobic gram-negative rods may maintain colonization resistance.

* Corresponding author. Mailing address: Infectious Diseases Section (111 F), VA Medical Center West Los Angeles, 11301 Wilshire Blvd., Los Angeles, CA 90073. Phone: (310) 268-3678. Fax: (310) 268-4928. E-mail: sidfinegol{at}aol.com.

Antimicrobial Agents and Chemotherapy, December 2004, p. 4898-4902, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4898-4902.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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