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Antimicrobial Agents and Chemotherapy, December 2004, p. 4907-4910, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4907-4910.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

A Subinhibitory Concentration of Clarithromycin Inhibits Mycobacterium avium Biofilm Formation

George Carter,1 Lowell S. Young,1 and Luiz E. Bermudez1,2*

Kuzell Institute, California Pacific Medical Center Research Institute, San Francisco, California,1 Department of Biomedical Sciences, College of Veterinary Medicine, and Department of Microbiology, College of Science, Oregon State University, Corvallis, Oregon2

Received 22 December 2003/ Returned for modification 8 February 2004/ Accepted 27 July 2004

Mycobacterium avium causes disseminated infection in immunosuppressed individuals and lung infection in patients with chronic lung diseases. M. avium forms biofilm in the environment and possibly in human airways. Antibiotics with activity against the bacterium could inhibit biofilm formation. Clarithromycin inhibits biofilm formation but has no activity against established biofilm.

* Corresponding author. Mailing address: 105 Dryden Hall, Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331. Phone: (541) 737-6538. Fax: (541) 737-8035. E-mail: luiz.bermudez{at}oregonstate.edu.

Antimicrobial Agents and Chemotherapy, December 2004, p. 4907-4910, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4907-4910.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Bermudez, L. E., Motamedi, N., Chee, C., Baimukanova, G., Kolonoski, P., Inderlied, C., Aralar, P., Wang, G., Phan, L. T., Young, L. S. (2007). EDP-420, a Bicyclolide (Bridged Bicyclic Macrolide), Is Active against Mycobacterium avium. Antimicrob. Agents Chemother. 51: 1666-1670 [Abstract] [Full Text]  


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