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Antimicrobial Agents and Chemotherapy, December 2004, p. 4911-4914, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4911-4914.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Need for Early Antifungal Treatment Confirmed in Experimental Disseminated Candida albicans Infection

Donna M. MacCallum and Frank C. Odds*

Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, Aberdeen, United Kingdom

Received 14 May 2004/ Returned for modification 18 June 2004/ Accepted 8 August 2004

Groups of mice infected intravenously with Candida albicans were treated intraperitoneally with amphotericin B, caspofungin, or fluconazole, starting at intervals before and after challenge. Survival was longest and tissue burdens were most reduced with early treatment, and survival times fell proportionately as treatment was delayed, reinforcing clinical recommendations for the earliest possible initiation of antifungal therapy.

* Corresponding author. Mailing address: FRCPath, Aberdeen Fungal Group, Institute of Medical Sciences, Aberdeen AB25 2ZD, United Kingdom. Phone and fax: 44 1224 555828. E-mail: f.odds{at}abdn.ac.uk.

Antimicrobial Agents and Chemotherapy, December 2004, p. 4911-4914, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4911-4914.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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