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Antimicrobial Agents and Chemotherapy, February 2004, p. 626-628, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.626-628.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Class 1 Integron Containing Metallo-ß-Lactamase Gene bla_VIM-2 in Pseudomonas aeruginosa Clinical Strains Isolated in Japan

Akita Prefectural Institute of Public Health, 6-6 Sensyu kubota-machi, Akita 010-0874,¹ Akita Kumiai General Hospital, 273-1 Iijima aza nishibukuro, Akita 011-0911,² Central Research Laboratory,³ Department of Pathology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan⁴

Received 8 July 2003/ Returned for modification 2 October 2003/ Accepted 22 October 2003

Four bla_VIM-2 gene-harboring Pseudomonas aeruginosa strains were identified. These strains possessed a class 1 integron harboring ORF1, bla_VIM-2, and aacA4 gene cassettes. The transposon-mediated horizontal spread of the bla_VIM-2 gene among these strains was suggested, which increases the threat that the bla_VIM-2 gene will disseminate among diverse genera of bacteria.

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