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Antimicrobial Agents and Chemotherapy, February 2004, p. 632-634, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.632-634.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Differential Diffusions of Indinavir and Lopinavir in Genital Secretions of Human Immunodeficiency Virus-Infected Women

Odile Launay,1* Michel Tod,2 Kamel Louchahi,2 Linda Belarbi,1 Olivier Bouchaud,1 Nathalie Mémain,1 Olivier Petitjean,2 Michel Robineau,1 Loïc Guillevin,1,{dagger} and Olivier Lortholary1,{ddagger}

Fédération de Médecine Interne, Maladies Infectieuses et Tropicales and UPRES EA 3409,1 Département de Pharmacotoxicologie, Hôpital Avicenne, AP-HP, Université Paris-Nord, Bobigny, France2

Received 10 July 2003/ Returned for modification 4 September 2003/ Accepted 4 November 2003

Plasma and cervicovaginal secretion (CVS) samples were collected from 19 human immunodeficiency virus type 1-infected women on lopinavir- or indinavir-containing regimens. Lopinavir and indinavir were detectable in 29 and 93% of CVS samples, respectively, a finding that may be ascribed to these drugs' differences in protein binding and pKa. The relationship between lopinavir and indinavir pharmacodynamics and viral evolution in the female genital tract should be assessed over time.

* Corresponding author. Present address: Centre Cochin-Pasteur d'Essais Vaccinaux, Service de Médecine Interne, Hôpital Cochin, AP-HP 27, rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France. Phone: (33) 1 43 25 38 67. Fax: (33) 1 40 46 93 08. E-mail: odile.launay{at}cch.ap-hop-paris.fr.

{dagger} Present address: Service de Médecine Interne, Hôpital Cochin, AP-HP, Paris, France.

{ddagger} Present address: Service de Maladies Infectieuses et Tropicales, Hôpital Necker, AP-HP, Paris, France.

Antimicrobial Agents and Chemotherapy, February 2004, p. 632-634, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.632-634.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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Copyright © 2004 by the American Society for Microbiology. All rights reserved.