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Antimicrobial Agents and Chemotherapy, February 2004, p. 641-643, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.641-643.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Safety and Efficacy of Antimicrobial Peptides against Naturally Acquired Leishmaniasis

J. Alberola,1* A. Rodríguez,1 O. Francino,2 X. Roura,3 L. Rivas,4 and D. Andreu5

Departament de Farmacologia, Terapèutica i Toxicologia,1 Departament de Ciència Animal i dels Aliments,2 Hospital Clínic Veterinari, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona,3 Centro de Investigaciones Biológicas, Velázquez 144, 28006 Madrid,4 Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain5

Received 21 July 2003/ Returned for modification 19 September 2003/ Accepted 8 October 2003

Leishmaniases, which are important causes of morbidity and mortality in humans and dogs, are extremely difficult to treat. Antimicrobial peptides are rarely used as alternative treatments for naturally acquired parasitic diseases. Here we report that the acylated synthetic antimicrobial peptide Oct-CA(1-7)M(2-9) is safe and effective for treating naturally acquired canine leishmaniasis.

* Corresponding author. Mailing address: Departament de Farmacologia, Terapèutica i Toxicologia, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. Phone: 34 93 581 1532. Fax: 34 93 581 2217. E-mail: Jordi.Alberola{at}uab.es.

Antimicrobial Agents and Chemotherapy, February 2004, p. 641-643, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.641-643.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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