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Antimicrobial Agents and Chemotherapy, February 2004, p. 648-650, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.648-650.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Emergence in Klebsiella pneumoniae and Enterobacter cloacae Clinical Isolates of the VIM-4 Metallo-ß-Lactamase Encoded by a Conjugative Plasmid

Francesco Luzzaro,1 Jean-Denis Docquier,2 Céline Colinon,2 Andrea Endimiani,1 Gianluigi Lombardi,1 Gianfranco Amicosante,3 Gian Maria Rossolini,2 and Antonio Toniolo1*

Laboratorio di Microbiologia, Ospedale di Circolo, and Università dell'Insubria, I-21100 Varese,1 Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, I-53100 Siena,2 Dipartimento di Scienze e Tecnologie Biomediche, Università di L'Aquila, I-67100 L'Aquila, Italy3

Received 13 March 2003/ Returned for modification 7 July 2003/ Accepted 19 October 2003

Resistance to carbapenems is an emerging problem among gram-negative hospital pathogens. A transferable plasmid encoding the VIM-4 metallo-ß-lactamase was detected in isolates of Klebsiella pneumoniae and Enterobacter cloacae obtained from a single patient under carbapenem therapy. Thus, enterobacteria appear to increasingly contribute to the spread of VIM-type enzymes.

* Corresponding author. Mailing address: Laboratorio di Microbiologia, Ospedale di Circolo e Università dell'Insubria, Viale Borri 57, 21100 Varese, Italy. Phone: 39-0332-278309. Fax: 39-0332-260517. E-mail: antonio.toniolo{at}ospedale.varese.it.

Antimicrobial Agents and Chemotherapy, February 2004, p. 648-650, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.648-650.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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