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Antimicrobial Agents and Chemotherapy, February 2004, p. 659-662, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.659-662.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Pharmacokinetics of DA-7867, a New Oxazolidinone, after Intravenous or Oral Administration to Rats: Intestinal First-Pass Effect

Soo K. Bae,1 Won-Suk Chung,1 Eun J. Kim,1,2 Jae K. Rhee,2 Jong W. Kwon,2 Won B. Kim,2 and Myung G. Lee1*

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Kwanak-Gu, Seoul 151-742,1 Research Laboratory, Dong-A Pharmaceutical Company, Ltd., Yongin, Kyunggi-Do 449-900, Korea2

Received 31 January 2003/ Returned for modification 12 July 2003/ Accepted 4 October 2003

Pharmacokinetic parameters of DA-7867 were dose independent after both intravenous administration and oral administration (at doses of 1 to 20 mg/kg of body weight) to rats. After oral administration of DA-7867 to rats at a dose of 10 mg/kg, approximately 8.27% of oral dose was not absorbed from the gastrointestinal tract, F was 70.8%, and approximately 21.8% of the oral dose was eliminated by the intestine (intestinal first-pass effect).

* Corresponding author. Mailing address: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, Korea. Phone: 822-880-7855. Fax: 822-889-8693. E-mail: leemg{at}snu.ac.kr.

Antimicrobial Agents and Chemotherapy, February 2004, p. 659-662, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.659-662.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Yoon, E. J., Jo, Y. W., Choi, S. H., Lee, T. H., Rhee, J. K., Yoo, M., Shim, M. J., Choi, E. C. (2005). In Vitro and In Vivo Activities of DA-7867, a New Oxazolidinone, against Aerobic Gram-Positive Bacteria. Antimicrob. Agents Chemother. 49: 2498-2500 [Abstract] [Full Text]  
  • Shin, J. H., Choi, K. Y., Kim, Y. C., Lee, M. G. (2004). Dose-Dependent Pharmacokinetics of Itraconazole after Intravenous or Oral Administration to Rats: Intestinal First-Pass Effect. Antimicrob. Agents Chemother. 48: 1756-1762 [Abstract] [Full Text]  


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