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Antimicrobial Agents and Chemotherapy, February 2004, p. 666-669, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.666-669.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Class 1 Integrons Increase Trimethoprim-Sulfamethoxazole MICs against Epidemiologically Unrelated Stenotrophomonas maltophilia Isolates

Raquel Barbolla,1 Mariana Catalano,1 Betina E. Orman,1 Angela Famiglietti,2 Carlos Vay,2 Jorgelina Smayevsky,3 Daniela Centrón,1* and Silvia A. Piñeiro1,{dagger}

Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina,1 Laboratorio de Bacteriología, Departamento de Análisis Clínicos, Hospital de Clínicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires,2 Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Buenos Aires, Argentina3

Received 30 December 2002/ Returned for modification 16 May 2003/ Accepted 2 November 2003

Twenty-five plasmid-specified antimicrobial resistance determinants common to gram-negative bacilli from nosocomial infection were investigated from 31 Stenotrophomonas maltophilia isolates. Twenty-four clones were identified by pulsed-field gel electrophoresis, and in three clones that exhibited an increased trimethoprim-sulfamethoxazole MIC, the sul1 determinant was found. These results support not only the higher spread of class 1 integrons compared to other mechanisms but also the potential limitation of using trimethoprim-sulfamethoxazole for therapy of severe S. maltophilia infections.

* Corresponding author. Mailing address: Dept. Microbiología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, P-12, 1121 Buenos Aires, Argentina. Phone: 54 11 4963 6669. Fax: 54 11 4508 3705. E-mail: dcentron{at}fmed.uba.ar.

{dagger} Present address: Department of Biomedical Sciences, University of Maryland, Baltimore, MD 21201.

Antimicrobial Agents and Chemotherapy, February 2004, p. 666-669, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.666-669.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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