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Antimicrobial Agents and Chemotherapy, February 2004, p. 670-672, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.670-672.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Penetration of Linezolid into the Anterior Chamber (Aqueous Humor) of the Human Eye after Intravenous Administration

E. García Vázquez,1* J. Mensa,1 Y. López,2 P. Díaz Couchard,3 D. Soy,4 J. R. Fontenla,3 M. Sarasa,2 X. Carné,2 and E. Montull5

Institut d'Infeccions i Immunologia,1 Unitat d'Avaluació Suport i Prevenció,2 Servei d'oftalmologia,3 Servei de Farmacia,4 Medical Department, Pfizer Spain, Hospital Clínic, 08036 Barcelona, Spain5

Received 25 June 2003/ Returned for modification 13 August 2003/ Accepted 14 October 2003

We determined the linezolid concentrations in serum samples and aqueous humors (AHs) from 21 patients undergoing cataract extraction. Cataract removal was performed at various times (from 60 to 270 min) after the end of a 30-min infusion of 600 mg of linezolid. Serum samples were obtained 1 h after the end of linezolid administration to determine the maximum concentration of linezolid (Cmax); AHs and a second serum sample were taken simultaneously during the operation, and the concentrations of linezolid in AH (CAH) and serum (CS) were determined. The mean CAH 1 h after linezolid administration was 4.94 µg/ml, and the mean ratio of CAH to CS (R = CAH/CS) was 0.43. All patients had a CAH of >2 µg/ml, which was higher than the MIC at which 90% of Staphylococcus epidermidis strains are inhibited.

* Corresponding author. Mailing address: Servicio de Infecciones, Hospital Clínic, C/ Villarroel 170, 08036 Barcelona, Spain. Phone: 00 34 93 227 55 29. Fax: 00 34 93 4514438. E-mail: egarciav{at}clinic.ub.es.

Antimicrobial Agents and Chemotherapy, February 2004, p. 670-672, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.670-672.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Horcajada, J. P., Atienza, R., Sarasa, M., Soy, D., Adan, A., Mensa, J. (2009). Pharmacokinetics of linezolid in human non-inflamed vitreous after systemic administration. J Antimicrob Chemother 63: 550-552 [Abstract] [Full Text]  
  • Prydal, J I, Jenkins, D R, Lovering, A, Watts, A (2005). The pharmacokinetics of linezolid in the non-inflamed human eye. Br J Ophthalmol 89: 1418-1419 [Abstract] [Full Text]  


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