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Antimicrobial Agents and Chemotherapy, February 2004, p. 677-680, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.677-680.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Telithromycin Susceptibility and Genomic Diversity of Macrolide-Resistant Serotype III Group B Streptococci Isolated in Perinatal Infections

Edouard Bingen,* Catherine Doit, Philippe Bidet, Naima Brahimi, and Dominique Deforche

Laboratoire d'Études de Génétique Bactérienne dans les Infections de l'Enfant (EA3105), Service de Microbiologie, Hôpital Robert Debré (AP-HP), Université Denis Diderot-Paris 7, 75019 Paris, France

Received 19 June 2003/ Returned for modification 21 September 2003/ Accepted 9 November 2003

We studied the telithromycin, erythromycin, azithromycin, and clindamycin susceptibilities of serotype III macrolide-resistant group B streptococci, together with genetic mechanisms of resistance and genomic diversity. ermB, ermA, and mefA were found in, respectively, 57, 32, and 9% of isolates. The telithromycin MIC at which 90% of isolates were inhibited was 0.5 µg/ml. Macrolide resistance was associated with dissemination of resistance determinants among isolates of different genetic backgrounds.

* Corresponding author. Mailing address: Service de Microbiologie, Hôpital Robert Debré, 48, Blvd. Sérurier, 75019 Paris, France. Phone: 33 1 40 03 23 40. Fax: 33 1 40 03 24 50. E-mail: edouard.bingen{at}rdb.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, February 2004, p. 677-680, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.677-680.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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