This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Dadachova, E. Articles by Casadevall, A. Search for Related Content PubMed PubMed Citation Articles by Dadachova, E. Articles by Casadevall, A.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, March 2004, p. 1004-1006, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1004-1006.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Evaluation of Acute Hematologic and Long-Term Pulmonary Toxicities of Radioimmunotherapy of Cryptococcus neoformans Infection in Murine Models

Department of Nuclear Medicine,¹ Department of Medicine,⁴ Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx,⁵ Vet Biomedical Sciences, Cornell University, Ithaca, New York,³ Institute for Transuranium Elements, Heidelberg, Germany²

Received 27 October 2003/ Returned for modification 12 November 2003/ Accepted 19 November 2003

We evaluated acute hematological and long-term pulmonary toxicity of radioimmunotherapy in murine models of Cryptococcus neoformans infection. Activities up to 250 µCi were well tolerated by healthy A/JCr mice for ²¹³Bi-18B7 and ¹⁸⁸Re-18B7 monoclonal antibodies. In infected mice, doses up to 150 µCi produced only transient toxicity. The lungs of treated mice had no evidence of radiation fibrosis.

This article has been cited by other articles:

• Dadachova, E., Bryan, R. A., Huang, X., Ortiz, G., Moadel, T., Casadevall, A. (2007). Comparative Evaluation of Capsular Polysaccharide-Specific IgM and IgG Antibodies and F(ab')2 and Fab Fragments as Delivery Vehicles for Radioimmunotherapy of Fungal Infection. Clin. Cancer Res. 13: 5629s-5635s [Abstract] [Full Text]  
• Martinez, L. R., Bryan, R. A., Apostolidis, C., Morgenstern, A., Casadevall, A., Dadachova, E. (2006). Antibody-guided alpha radiation effectively damages fungal biofilms.. Antimicrob. Agents Chemother. 50: 2132-2136 [Abstract] [Full Text]  
• Dadachova, E., Burns, T., Bryan, R. A., Apostolidis, C., Brechbiel, M. W., Nosanchuk, J. D., Casadevall, A., Pirofski, L. (2004). Feasibility of Radioimmunotherapy of Experimental Pneumococcal Infection. Antimicrob. Agents Chemother. 48: 1624-1629 [Abstract] [Full Text]