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Antimicrobial Agents and Chemotherapy, March 2004, p. 1017-1020, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1017-1020.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Quantitative Analysis of a Parasitic Antiviral Strategy

Hwijin Kim and John Yin*

Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706-1607

Received 31 July 2003/ Returned for modification 25 September 2003/ Accepted 2 December 2003

We extended a computer simulation of viral intracellular growth to study a parasitic antiviral strategy that diverts the viral replicase toward parasite growth. This strategy inhibited virus growth over a wide range of conditions, while minimizing host cell perturbations. Such parasitic strategies may inhibit the development of drug-resistant virus strains.

* Corresponding author. Mailing address: 3633 Engineering Hall, 1415 Engineering Dr., Madison, WI 53706-1607. Phone: (608) 265-3779. Fax: (608) 262-5434. E-mail: yin{at}engr.wisc.edu.

Antimicrobial Agents and Chemotherapy, March 2004, p. 1017-1020, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1017-1020.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Stauffer Thompson, K. A., Rempala, G. A., Yin, J. (2009). Multiple-hit inhibition of infection by defective interfering particles. J. Gen. Virol. 90: 888-899 [Abstract] [Full Text]  


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