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Antimicrobial Agents and Chemotherapy, March 2004, p. 1021-1023, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1021-1023.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Ribosomal Mutations in Arcanobacterium pyogenes Confer a Unique Spectrum of Macrolide Resistance

B. Helen Jost,* Hien T. Trinh, J. Glenn Songer, and Stephen J. Billington

Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, Arizona 85721

Received 29 August 2003/ Returned for modification 13 November 2003/ Accepted 26 November 2003

Four macrolide-resistant Arcanobacterium pyogenes isolates contained A2058T, A2058G, or C2611G (Escherichia coli numbering) mutations in their 23S rRNA genes. While these mutations conferred resistance to erythromycin, oleandomycin, and spiramycin, they did not confer resistance to tylosin.

* Corresponding author. Mailing address: Department of Veterinary Science and Microbiology, The University of Arizona, 1117 East Lowell St., Tucson, AZ 85721. Phone: (520) 621-2745. Fax: (520) 621-6366. E-mail: jost{at}u.arizona.edu.

Antimicrobial Agents and Chemotherapy, March 2004, p. 1021-1023, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1021-1023.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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